Niclosamide CAS NO.50-65-7

Niclosamide is a lampricide and molluscicide. It kills a wide variety of snails, cestodes（Taenia saginata and Taeniasolium) and Cercariae by affectin…

Niclosamide is a lampricide and molluscicide. It kills a wide variety of snails, cestodes（Taenia saginata and Taeniasolium) and Cercariae by affecting the respiration and the carbohydrate metabolism. It probably disturbs oxidation processes by inhibiting oxygen uptake. The main target pest in agricultural use is the golden apple snail (Pomacea canaliculata) in paddy fields (rice-cultivation). It is also used in public health for control of snails which are the intermediate hosts of Schistosoma spp., the infectious agents of schistosomiasis. The compound is quickly metabolized in water and does not exhibit a long-term effect (Andrews et al, 1983). It is also applied to commercially managed fish ponds, in order to clean them from undesirable fish prior to re-filling the pond. Niclosamide is highly toxic to fish but, due to its short half-life in water, the batch of new fish may be added only a few days after application of the pesticide.